I think bungpeng was refering to software design, not UI design. I tend to agree with him on this one - getting the software correctly designed and planned is a lot more important than choice of language, especially under .Net where most languages are very similar in what they can do.
Vb.Net isn't really that much easier than C#, the core principles are the same, the basic language structures and runtime support are the same. This is one of the ideas behind .Net - allow people to choose the language that suits them rather than force them into a particular language. People can focus on solving problems rather than struggling with a language they don't like.